genes are those indispensable for the survival of an organism, and
therefore are considered a foundation of life. DEG hosts records of
currently available essential genes among a wide range of organisms.
For prokaryotes, DEG contains essential genes in more than 10 bacteria,
such as E. coli, B. subtilis, H. pylori, S. pneumoniae, M. genitalium
and H. influenzae, whereas for eukaryotes, DEG contains those in yeast,
humans, mice, worms, fruit flies, zebra fish and the plant A. thaliana.
Users can Blast query sequences against DEG, and can also search for
essential genes by their functions and names. Essential gene products
comprise excellent targets for antibacterial drugs. Essential genes in
a bacterium constitute a minimal genome, forming a set of functional
modules, which play key roles in the emerging field, synthetic biology.
|DEG 6.8, updated on November 4, 2011|